Galeria Melissa is one of T+L's Definitive Guide to São Paulo.

1. Galeria Melissa

Shoe Store · Cerqueira César · R. Oscar Freire, 827 (R. Bela Cintra), São Paulo, SP

Travel + LeisureTravel + Leisure: Expect stylish sandals, sneakers, and kitten heels by Vivienne Westwood, Karim Rashid, and Jason Wu at this mecca for plastic and rubber footwear.

Adriana Barra Hotel is one of T+L's Definitive Guide to São Paulo.

2. Adriana Barra Hotel

6.6
Women's Store · Cerqueira César · Al. Franca, 1243 (R. Haddock Lobo), São Paulo, SP

Travel + LeisureTravel + Leisure: Barra’s flagship store displays colorful, boho-chic dresses and tunics on luggage trolleys. Don’t miss her vivid prints for the home-furnishings collection on the second floor.

Museu de Arte de São Paulo (MASP) is one of T+L's Definitive Guide to São Paulo.

3. Museu de Arte de São Paulo (MASP)

9.4
Art Museum · Avenida Paulista · Av. Paulista, 1578 (R. Prof. Otávio Mendes), São Paulo, SP

Travel + LeisureTravel + Leisure: This 1968 Modernist building houses one of the most comprehensive Western art collections (ranging from Botticelli to Diego Rivera) in the Southern Hemisphere.

Galeria Raquel Arnaud is one of T+L's Definitive Guide to São Paulo.

4. Galeria Raquel Arnaud

Art Gallery · Vila Madalena · Rua Fidalga, 125, São Paulo, SP

Travel + LeisureTravel + Leisure: Contemporary art gallery representing more than 20 Brazilian artists, including sculptor Frida Baranek.

Galeria Vermelho is one of T+L's Definitive Guide to São Paulo.

5. Galeria Vermelho

8.8
Art Gallery · Consolação · Minas Gerais, 350, São Paulo, SP

Travel + LeisureTravel + Leisure: Vermelho showcases experimental works by international talent such as provocative Danish art collective Superflex.

Galeria Fortes Vilaça is one of T+L's Definitive Guide to São Paulo.

6. Galeria Fortes Vilaça

8.7
Art Gallery · Vila Madalena · R. Fradique Coutinho, 1500 (R. Purpurina), São Paulo, SP

Travel + LeisureTravel + Leisure: São Paulo is a hotbed for contemporary art galleries; this one, located in Vila Madalena, is one of the city’s largest spaces.

Auditório Ibirapuera is one of T+L's Definitive Guide to São Paulo.

7. Auditório Ibirapuera

9.4
Music Venue · Ibirapuera · Av. Pedro Álvares Cabral, s/n (Portão 1, 2 e 3 (carros)), São Paulo, SP

Travel + LeisureTravel + Leisure: Leave time to see Oscar Niemeyer’s indoor-outdoor music auditorium in Ibirapuera Park.

Beco do Batman is one of T+L's Definitive Guide to São Paulo.

8. Beco do Batman

9.3
Street Art · Vila Madalena · R. Gonçalo Afonso, São Paulo, SP

Travel + LeisureTravel + Leisure: The long, graffiti-lined alley in the Vila Madalena district continually evolves as street artists add new works.

Hotel Emiliano is one of T+L's Definitive Guide to São Paulo.

9. Hotel Emiliano

9.1
Hotel · Cerqueira César · Rua Oscar Freire, 384 (Entre R. Pd. João Manuel e Al. Min. Rocha Azevedo), São Paulo, SP

Travel + LeisureTravel + Leisure: The 57 white-on-white rooms here have furniture by the Compana Brothers and Eames. They’re best for stylish travelers seeking easy access to the city’s top boutiques.

Hotel Fasano São Paulo is one of T+L's Definitive Guide to São Paulo.

10. Hotel Fasano São Paulo

8.7
Hotel · Cerqueira César · R. Vitório Fasano, 88 (Jd. Paulista), São Paulo, SP

Travel + LeisureTravel + Leisure: A good fit for sophisticates and fashion gurus, this sexy retreat has clubby leather armchairs and Brazilian modern art. The Italian restaurant is a see-and-be-seen spot for the creative set.

Grand Hyatt São Paulo is one of T+L's Definitive Guide to São Paulo.

11. Grand Hyatt São Paulo

9.4
Hotel · Brooklin Novo · Av. das Nações Unidas, 13301, São Paulo, SP

Travel + LeisureTravel + Leisure: All 466 spacious rooms have floor-to-ceiling windows that look out onto the pastel-colored rooftops. The 2,000-plus bottle library lounge has one of the top wine lists in town.

Hotel Unique is one of T+L's Definitive Guide to São Paulo.

12. Hotel Unique

9.4
Hotel · Jardim Paulista · Av. Brig. Luís Antônio, 4700 (R. Groenlândia), São Paulo, SP

Travel + LeisureTravel + Leisure: A design junkie’s dream: the 95-room property by architect Ruy Ohtake has curved hallways, sloped walls, and oversize round windows. Best for architecture geeks.

D.O.M. is one of T+L's Definitive Guide to São Paulo.

13. D.O.M.

9.3
Brazilian Restaurant · Cerqueira César · R. Barão de Capanema, 549, São Paulo, SP

Travel + LeisureTravel + Leisure: A required stop for foodies (and big-name chefs from Ducasse to Adrià). Try the shrimp infused with cashew juice and tamarind and the banana-lime dessert.

Epice is one of T+L's Definitive Guide to São Paulo.

14. Epice

8.2
Restaurant · Cerqueira César · R. Haddock Lobo, 1002 (Av. Paulista), São Paulo, SP

Travel + LeisureTravel + Leisure: Alberto Landgraf’s menu plays with textures: a deceptively simple entrée presents squash entrée three ways—raw, as a cream, and in gnocchi.

Maní is one of T+L's Definitive Guide to São Paulo.

15. Maní

9.4
Brazilian Restaurant · Jardim Paulistano · R. Joaquim Antunes, 210 (Av. Rebouças), São Paulo, SP

Travel + LeisureTravel + Leisure: Classic dishes such as feijoada, a hearty bean, beef, and pork stew, get a modern spin here; the chef and her husband both worked at El Celler de Can Roca, one of Spain’s molecular gastronomy temples.

Tordesilhas is one of T+L's Definitive Guide to São Paulo.

16. Tordesilhas

8.9
Brazilian Restaurant · Cerqueira César · Al. Tietê, 489 (R. da Consolação), São Paulo, SP

Travel + LeisureTravel + Leisure: Chef Mara Salles still uses the recipes she learned from her mother. Order the tender duck braised in spicy cassava broth, followed by house-made tapioca ice cream.

Maria Brigadeiro is one of T+L's Definitive Guide to São Paulo.

17. Maria Brigadeiro

8.6
Dessert Shop · Jardim Paulista · R. Capote Valente, 68, São Paulo, SP

Travel + LeisureTravel + Leisure: Stop in for brigadeiros, cocoa-filled bonbons made in dozens of flavors (pistachio and cachaça are two).

Coffee Lab is one of T+L's Definitive Guide to São Paulo.

18. Coffee Lab

9.4
Coffee Shop · Vila Madalena · R. Fradique Coutinho, 1340, São Paulo, SP

Travel + LeisureTravel + Leisure: The artisanal coffee here is brewed using roasted beans from small Brazilian farms. Order a steaming cup of Bourbon Vermelho.

Pão de Queijo is one of T+L's Definitive Guide to São Paulo.

19. Pão de Queijo

7.8
Coffee Shop · Cerqueira César · R. Haddock Lobo, 1408 (Al. Lorena), São Paulo, SP

Travel + LeisureTravel + Leisure: Haddock Lobo’s fresh batches of pão de queijo—irresistibly chewy, buttery bread made with cassava flou—are baked daily at this pocket-size shop.

Jun Sakamoto is one of T+L's Definitive Guide to São Paulo.

20. Jun Sakamoto

8.1
Japanese Restaurant · Cerqueira César · R. Lisboa, 55, São Paulo, SP

Travel + LeisureTravel + Leisure: The sushi in São Paulo is top-notch, and this spot is a popular favorite.

Choque Cultural is one of T+L's Definitive Guide to São Paulo.

21. Choque Cultural

8.5
Art Gallery · Jardim Paulista · R. João Moura, 997, São Paulo, SP

Travel + LeisureTravel + Leisure: Showcases innovative street art curated by owner Baixo Ribeiro.

Estudio Terpins is one of T+L's Definitive Guide to São Paulo.

22. Estudio Terpins

Art Gallery · Perdizes ·

Travel + LeisureTravel + Leisure: Where to go for stylish furnishings, including a great collection of sleek glass tables.

Amoreira is one of T+L's Definitive Guide to São Paulo.

23. Amoreira

7.0
Gift Shop · Alto de Pinheiros · R. Macunis, 510, São Paulo, SP

Travel + LeisureTravel + Leisure: Home decorators will love their one-of-a kind porcelain vases and bowls.

Frevo is one of T+L's Definitive Guide to São Paulo.

24. Frevo

8.5
Sandwich Place · Jardim Paulista · R. Oscar Freire, 603 (R. Augusta), São Paulo, SP

Travel + LeisureTravel + Leisure: Don’t miss the Beirute sandwich—pita bread filled with roast beef, mozzarella, and tomatoes.

Empório Sagarana is one of T+L's Definitive Guide to São Paulo.

25. Empório Sagarana

8.9
Beer Garden · Vila Romana · R. Marco Aurelio, 883 (R. Quirino Pucca), São Paulo, SP

Travel + LeisureTravel + Leisure: A great place to start your night out: Come here around 10 p.m. and order a refreshing glass of cachaça.

Suíte Savalas is one of T+L's Definitive Guide to São Paulo.

26. Suíte Savalas

7.5
Cocktail Bar · Higienópolis · R. Mato Grosso, 398, São Paulo, SP

Travel + LeisureTravel + Leisure: Classic cocktails—such as the amaretto-infused Corleone—are a specialty.

Casa 92 is one of T+L's Definitive Guide to São Paulo.

27. Casa 92

8.3
Nightclub · Pinheiros · R. Cristovão Gonçalves 92 (Av. Brg. Faria Lima), São Paulo, SP

Travel + LeisureTravel + Leisure: Hit the dance floor at this exclusive club (though there’s no velvet rope), which feels like a private home.

Oficina de Agosto 243 is one of T+L's Definitive Guide to São Paulo.

28. Oficina de Agosto 243

Design Studio · Vila Madalena · Rua Harmonia (Rua Faisão), São Paulo, SP

Travel + LeisureTravel + Leisure: The owners work with Minas Gerais-based craftsmen who produce rough-hewn trunks, whitewashed-framed mirrors, and brightly hued wooden sculptures.

Projeto Terra is one of T+L's Definitive Guide to São Paulo.

29. Projeto Terra

Gift Shop · Pinheiros · São Paulo, SP

Travel + LeisureTravel + Leisure: The woven baskets, wooden bracelets, and carved objets d’art here are all made by regional artisans using sustainable materials.

Mocotó Restaurante & Cachaçaria is one of T+L's Definitive Guide to São Paulo.

30. Mocotó Restaurante & Cachaçaria

9.5
Northeastern Brazilian Restaurant · Vila Medeiros · Av. Ns. do Loreto, 1100, São Paulo, SP

Travel + LeisureTravel + Leisure: Paulistas drive 45 minutes from the city center to sample Rodrigo Oliverira’s northern Brazilian specialties: mouth­watering torresmos (fried pig skin) and rich mocofava (cow-hoof soup with sausage).

Pizzaria Speranza is one of T+L's Definitive Guide to São Paulo.

31. Pizzaria Speranza

9.1
Pizza Place · Bixiga · R. Treze de Maio, 1004 (Av. Brigadeiro Luiz Antonio), São Paulo, SP

Travel + LeisureTravel + Leisure: Thanks to its sizable Italian community, São Paulo is famous for outstanding pizza; don’t miss the classic Neapolitan margherita here.