Flo & Santos is one of The 9 Best Places for Pepperoni in South Loop, Chicago.

1. Flo & Santos

8.8
1310 S Wabash Ave, Chicago, IL
Pizzeria · South Loop · 109 tips and reviews

Time Out Chicago KidsTime Out Chicago Kids: This parlor serves classic South Side–style ’za: It’s thin as matzo, cut into squares. Pizzas come with a crackly crust and toothsome, spicy pepperoni, which will be met with familiarity and delight. Read more.

Roosevelt CollectionRoosevelt Collection: Great pizza selection! We recommend Kai's Hawaiian or Jack & Papa's Pepperoni! (Ask for it to be cooked "crispy" if you like a little crunch!)

Mitch J.Mitch Johnson: Pizza is to die for. But there's also a really deep menu including Polish sausages and pierogis. Hearty food served in a pub atmosphere. Awesome.

Lou Malnati's Pizzeria is one of The 9 Best Places for Pepperoni in South Loop, Chicago.

2. Lou Malnati's Pizzeria

8.6
805 S State St (btwn 8th St & 9th St), Chicago, IL
Pizzeria · South Loop · 193 tips and reviews

Janice L.Janice Li: Pepperoni and sausage deep dish pizza was good! Beware of HUGE portions here, couldnt finish medium chicken salad. Slow service though

Colin N.Colin Nelson: Lou's pizza + pepperoni is the way to go

Viet D.Viet Dang: Pepperoni and sausage!

The Burger Point is one of The 9 Best Places for Pepperoni in South Loop, Chicago.

3. The Burger Point

7.9
1900 S State St (Archer & State), Chicago, IL
Burger Joint · South Loop · 59 tips and reviews

AskMenAskMen: Burgers such as the "Jersey Shore" topped with pepperoni, mozzarella and marinara are available, as well as a slew of sides such as wings, chili and fresh-cut russet fries. Read more.

Chicago TribuneChicago Tribune: GTL? The Jersey Shore burger at The Burger Point piles marinara sauce, fresh mozzarella and pepperoni on top of grass-fed beef, all on a brioche roll. Read more.

Jenny C.Jenny Ch: Love the spicy garlic wings! Very BW3-esque. Yum.

Giordano's is one of The 9 Best Places for Pepperoni in South Loop, Chicago.

4. Giordano's

8.4
1340 S Michigan Ave (at E 14th St), Chicago, IL
Pizzeria · South Loop · 47 tips and reviews

Susan W.Susan Wellford: The wait was long, but the payoff was great! We ordered a large deep dish pepperoni for 2 adults & 2 teen girls, and we ate every bit! Wow!! Best deep dish we've had. Ready to go back in a downtime.

Sarah D.Sarah Dineen: Expect to wait awhile but the deep dish pizza is excellent! The Leaning App Tower and Family Style Salad is a great deal, too. Ask for Zuri as your waitress - she's the best!

Misha M.Misha Moskalyk: For pizza lovers, definitely good place to visit. Deep dish pizza is amazing.

Armand's Victory Tap is one of The 9 Best Places for Pepperoni in South Loop, Chicago.

5. Armand's Victory Tap

9.2
1416 S Michigan Ave, Chicago, IL
Italian Restaurant · South Loop · 7 tips and reviews

Heather F.Heather Folsom: Some of the best service I've ever had! Everyone was so friendly! Gorgeous interior. Loved the On Tap Pinot Noir and the rolled eggplant app. Can't wait to come back when we are hungrier!

Honey L.Honey Little: Get the meatballs!!!

Zenaida S.Zenaida Samaniego: Great food, great service,

Roots Handmade Pizza- Printer's Row is one of The 9 Best Places for Pepperoni in South Loop, Chicago.

6. Roots Handmade Pizza- Printer's Row

8.3
744 S Dearborn St, Chicago, IL
Pizzeria · Printer's Row · 4 tips and reviews

Justin K.Justin Kadis: Everyone talks about the mozzarella sticks - they are a must! We enjoyed a half and half pie with pulled pork on one side and sausage on the other.

Mike H.Mike Hollatz: Good suff here

iselaisela: The handmade mozzarella sticks! Hands down the best!!! They ain’t lying people!!!

First Draft is one of The 9 Best Places for Pepperoni in South Loop, Chicago.

7. First Draft

8.2
649 S Clark St, Chicago, IL
Sports Bar · Printer's Row · 22 tips and reviews

Allison K.Allison Kaminski: Awesome service, super extensive beer selection and flights! What more can you ask for?? Oh, tasty food too! Get the porksicles and poutine!

Heather F.Heather Folsom: Simply put, we will be back ASAP. Poutine, wild boar meatballs w/cheddar grits, mac, & gnocchi were all phenomenal. Impressive beer list and server Amanda was spectacular- so funny & knowledgeable!

Andrew S.Andrew Stiles: Good for sports if you can get a table. The goose island Ogden is a good local craft beer. Pizza was a pleasant surprise.

Kasey's Tavern is one of The 9 Best Places for Pepperoni in South Loop, Chicago.

8. Kasey's Tavern

8.7
701 S Dearborn St (btwn Harrison & Polk St), Chicago, IL
Pub · Printer's Row · 71 tips and reviews

RobenRoben: Shelby is awesome & the beer selection is top drawer!

Bernardo B. M.Bernardo B. Mejia Huerta: WiFi: 3412kaseys try the Great Divide Chocolate Oak Aged Yeti!

Paul K.Paul Kim: Great beer selection, great service and not pretentious at all. Not much more to ask for.

Weather Mark Tavern is one of The 9 Best Places for Pepperoni in South Loop, Chicago.

9. Weather Mark Tavern

7.7
1503 S Michigan Ave, Chicago, IL
Bar · South Loop · 67 tips and reviews

Derek S.Derek Sohn: Best wings on the South Side! Great staff too.

StephenStephen: Check out the six new taps at Weather Mark! Awesome.

Mark S.Mark Stern: Follow us on twitter @weathermarktav