California Academy of Sciences is one of Night life.

1. California Academy of Sciences

9.6
Science Museum · Golden Gate Park · 55 Music Concourse Dr (at Martin Luther King Jr Dr), San Francisco, CA
Rye is one of Night life.

2. Rye

8.9
Cocktail Bar · Tenderloin · 688 Geary St (btwn Leavenworth & Jones), San Francisco, CA

Laura C.Laura C: For after dinner drinks, head to Rye where the bartenders will concoct the drink of your choice using the freshest ingredients.

Top of the Mark is one of Night life.

3. Top of the Mark

7.9
Hotel Bar · Nob Hill · 1 Nob Hl (inside the Intercontinental Mark Hopkins Hotel), San Francisco, CA
The Alembic is one of Night life.

4. The Alembic

9.2
Cocktail Bar · Haight Ashbury · 1725 Haight St (btwn Cole & Shrader St.), San Francisco, CA
Muka is one of Night life.

5. Muka

8.1
Bar · Civic Center · 370 Grove St (at Gough St), San Francisco, CA
The Ambassador is one of Night life.

6. The Ambassador

Nightclub · Tenderloin · 673 Geary St (btw Leavenworth & Jones), San Francisco, CA

AskMenAskMen: With its overstuffed leather booths, decadently long bar and phones at every table, puts the intrigue and romance back into cocktailing. Read more.

CHAMBERS eat + drink is one of Night life.

7. CHAMBERS eat + drink

8.6
Lounge · Tenderloin · 601 Eddy St (btwn Polk St. & Larkin St.), San Francisco, CA

AskMenAskMen: The space inside the Phoenix Hotel formerly occupied by Bambhudda Lounge, it’s decorated kind of like a cool ex-goth with gobs of good taste and cash got to have her way with the interior

Two Sisters Bar & Books is one of Night life.

8. Two Sisters Bar & Books

9.0
Cocktail Bar · Hayes Valley · 579 Hayes St (at Laguna St), San Francisco, CA
The Starlight Room is one of Night life.

9. The Starlight Room

7.7
Nightclub · Downtown San Francisco-Union Square · 450 Powell St (at Sutter St.), San Francisco, CA
The Alembic is one of Night life.

10. The Alembic

9.2
Cocktail Bar · Haight Ashbury · 1725 Haight St (btwn Cole & Shrader St.), San Francisco, CA

Travel ChannelTravel Channel: This place has high quality drinks and a small, but interesting menu – including choices like duck hearts & quail eggs. As recommended by Travel Channel host, Anthony Bourdain.

Zam Zam is one of Night life.

11. Zam Zam

7.9
Dive Bar · Haight Ashbury · 1633 Haight St (at Clayton St), San Francisco, CA

Travel ChannelTravel Channel: As recommended by Travel Channel host, Anthony Bourdain.

Tonga Room & Hurricane Bar is one of Night life.

12. Tonga Room & Hurricane Bar

8.3
Cocktail Bar · Nob Hill · 950 Mason St, San Francisco, CA

Travel ChannelTravel Channel: A genuine Tiki room/Polynesian restaurant at the Fairmont Hotel. Has a swimming pool turned bar & a rain/thunder show! Seen on Travel Channel’s The Layover with Anthony Bourdain.

Toronado is one of Night life.

13. Toronado

9.0
Bar · Lower Haight · 547 Haight St (btwn Fillmore & Steiner St), San Francisco, CA

Travel ChannelTravel Channel: With over 50 microbrews on tap and 100 bottled beers, this is a great stop for an afternoon drink. As seen on Travel Channel’s The Layover with Anthony Bourdain.

Noble is one of Night life.

14. Noble

5.7
Nightclub · Civic Center · 600 Polk St (at Turk St.), San Francisco, CA
Jones is one of Night life.

15. Jones

7.8
Cocktail Bar · Lower Nob Hill · 620 Jones St (at Geary St.), San Francisco, CA

Examiner.comExaminer.com: Dine under the stars on dishes such as seared ahi tuna with herb-citrus vinaigrette, filet mignon steak tartar with quail egg or ginger-soy glazed baby back ribs and apple-pepper slaw. Read more.

Swig is one of Night life.

16. Swig

6.8
Bar · Tenderloin · 561 Geary St (at Jones St.), San Francisco, CA

Chad W.Chad Williams: Very stylish spot. 250 whiskey selections. Fireplace and couches.

Bourbon & Branch is one of Night life.

17. Bourbon & Branch

9.1
Speakeasy · Tenderloin · 501 Jones St (at O'Farrell St), San Francisco, CA

EsquireEsquire: Congratulations, you've found one of Esquire's Best Bars in America. This place is a speakeasy with cocktails that would have made a pre-Prohibition Broadway dandy smile. Our vote: a daiquiri.

Vesuvio Cafe is one of Night life.

18. Vesuvio Cafe

8.8
Dive Bar · North Beach · 255 Columbus Ave (btwn Broadway and Pacific), San Francisco, CA

EsquireEsquire: Congratulations, you've found one of Esquire's Best Bars in America. No matter how many tourists drop in for a pint, it still feels as though it's full of locals. We recommend an Anchor Steam.

Rickhouse is one of Night life.

19. Rickhouse

8.8
Cocktail Bar · Downtown San Francisco-Union Square · 246 Kearny St (at Bush St.), San Francisco, CA

AskMenAskMen: A place with a modern take on classic libations, and a clientele that's a raucous mix of office workers letting loose and mixology aficionados. Try the Sazerac with locally distilled Old Potrero Rye. Read more.

The View is one of Night life.

20. The View

8.4
Hotel Bar · SoMa · 55 4th St (at Marriott Marquis), San Francisco, CA

Jeff K.Jeff Koo: Downtown leave you feeling weary? Find some refuge high above the streets here where the drinks are pricey but the view sublime.

B Restaurant & Bar is one of Night life.

21. B Restaurant & Bar

8.0
Lounge · SoMa · 720 Howard St (btw 4th & 5th), San Francisco, CA
Temple Nightclub is one of Night life.

22. Temple Nightclub

6.7
Nightclub · SoMa · 540 Howard St (btwn 1st & 2nd St), San Francisco, CA
Olive Bar & Restaurant is one of Night life.

23. Olive Bar & Restaurant

Cocktail Bar · Tenderloin · 743 Larkin St (btwn O'Farrell and Ellis), San Francisco, CA

Eugene M.Eugene Mercado: The Baked Brie is amazing. Definitely a "must try."

Bar None is one of Night life.

24. Bar None

5.9
Bar · Union Street · 1980 Union St (at Buchanan), San Francisco, CA

Jason J.Jason Jackson: Tater tots! Heard 5 people in an hour order them and they were out. They must be good

The Ambassador is one of Night life.

25. The Ambassador

Nightclub · Tenderloin · 673 Geary St (btw Leavenworth & Jones), San Francisco, CA

CheapismCheapism: The $2 Tuesday happy hour offers sliders, bruschette, Tater Tots, chicken wings, quesadillas, and Caesar salads. Well drinks are also $2, as are 10 bottled and draft beers. Read more.

The Cosmopolitan is one of Night life.

26. The Cosmopolitan

American Restaurant · Financial District · 121 Spear St (btwn Mission & Howard), San Francisco, CA

CheapismCheapism: Try some half-priced bubbly every Wednesday in the lounge or covered patio. All Sparkling Wine and Champagne glasses are 1/2 price from 4pm to 10pm. Also try some of the diverse menu inside or out. Read more.

Rouge et Blanc is one of Night life.

27. Rouge et Blanc

7.2
Wine Bar · Downtown San Francisco-Union Square · 334 Grant Ave (at Bush St), San Francisco, CA
Chateau Montelena is one of Night life.

28. Chateau Montelena

Winery · Downtown San Francisco-Union Square · 1429 Tubbs Ln, Calistoga, CA
Butter is one of Night life.

29. Butter

7.9
Bar · SoMa · 354 11th St (btwn Harrison & Folsom), San Francisco, CA
The Republic is one of Night life.

30. The Republic

Sports Bar · Marina District · 3213 Scott St (at Lombard St), San Francisco, CA